Functional Genomics Core 

 



The Functional Genomics Core  (FGC) of the Institute for Research in Biomedicine  (IRB Barcelona, Catalunya, Spain) is open to work with researchers from academia and industry.

      We provide comprehensive support to your projects whenever genome-wide measurements of DNA or RNA are needed or gene expression should be manipulated.



Tools for Genomic Analysis

I miRNAs I transcriptomics I DNA copy numbers I ChIP-Seq I       
I genomic sequencing I SNPs I

Genome-wide measurements of DNA alterations and gene expression on the RNA level can be a challenge during research projects. FGC provides a complete service to work with you throughout the entire project.  In addition to cutting-edge tools like microarrays from Affymetrix  and NimbleGen  and Next Generation Sequencing by Illumina , FGC is ready to help with all questions related to your genomic project. Some examples are
  • What is the most efficient way to design my study?
  • How can I avoid roadblocks and hurdles during the project?
  • I have only a few 1,000 cells. Can I still perform genome-wide analysis?
  • How can I best isolate my samples?
  • Which platform(s) suit best for my needs?
  • How do I interprete the results?
  • What can I do best as follow-up?
Alteration of Gene Expression

I human shRNAs I mouse shRNAs I human ORF clones I

Reverse genetics needs efficient tools to alter gene expression. FGC provides close to 200,000 clones for genetic manipulation. These include all of Sigma's  TRC1 human and mouse shRNA clones for knock-down of expression, together with Open Biosystems  human ORF clones for over-expression. ORF clones also come handy as probes for in situ hybridization or northerns.

       shRNA clones come in lentivirus vectors for efficient infection of many cell types, including non-dividing ones.

       ORF clones contain the Gateway  system for hassle-free transfer into any kind of expression vector.


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